Takayuki Noguchi Selected Research

sivelestat

4/2010	The impact of oxidative stress levels on the clinical effectiveness of sivelestat in treating acute lung injury: an electron spin resonance study.
1/2009	Sivelestat treatment for acute respiratory distress syndrome in an infant.
8/2008	A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1.
1/2006	Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2).

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Takayuki Noguchi Research Topics

Disease

38	Inflammation (Inflammations) 01/2015 - 12/2007
22	Sepsis (Septicemia) 01/2015 - 04/2003
17	Acute Lung Injury 06/2015 - 03/2005
16	Ischemia 07/2012 - 06/2002
11	Reperfusion Injury 07/2012 - 08/2010
11	Pain (Aches) 06/2012 - 02/2004
7	Lung Injury 01/2015 - 03/2005
6	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2016 - 01/2007
6	Critical Illness (Critically Ill) 07/2012 - 07/2009
6	Edema (Dropsy) 12/2011 - 01/2007
5	Septic Shock (Toxic Shock Syndrome) 07/2012 - 04/2008
5	Acute Kidney Injury (Acute Renal Failure) 07/2012 - 09/2005
4	Neoplasms (Cancer) 03/2012 - 02/2004
4	Shock 06/2011 - 04/2007
4	Hyperglycemia 06/2011 - 08/2008
3	Infections 01/2015 - 09/2003
3	Fibrosis (Cirrhosis) 12/2012 - 06/2007
3	Disease Progression 07/2012 - 09/2008
3	Endotoxemia 12/2011 - 02/2009
3	Body Weight (Weight, Body) 12/2011 - 09/2007
3	Hemorrhage 12/2011 - 02/2009
3	Hyperthermia 07/2011 - 09/2007
2	Hypotension (Low Blood Pressure) 10/2012 - 01/2009
2	Renal Insufficiency (Renal Failure) 07/2012 - 01/2010
2	Chronic Pain 06/2012 - 12/2010
2	Hyperalgesia 06/2011 - 03/2009
2	Heat Stroke (Heatstroke) 10/2010 - 07/2010
2	Angina Pectoris 02/2010 - 11/2007
2	Tachycardia (Tachyarrhythmias) 02/2010 - 01/2009
2	Atrial Flutter (Flutter, Atrial) 02/2010 - 07/2005
2	Pancreatitis 10/2009 - 07/2009
2	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2009 - 12/2004

Drug/Important Bio-Agent (IBA)

23	LipopolysaccharidesIBA 12/2016 - 01/2007
21	CytokinesIBA 04/2014 - 04/2003
20	HMGB1 Protein (HMG1)IBA 06/2015 - 01/2007
8	AntioxidantsIBA 03/2013 - 01/2011
8	EndotoxinsIBA 12/2011 - 01/2008
7	AnticoagulantsIBA 12/2011 - 01/2008
6	Vitamin E FDA LinkGeneric 03/2013 - 03/2012
6	Insulin (Novolin)FDA Link 11/2011 - 08/2008
6	Opioid Analgesics (Opioids)IBA 06/2011 - 02/2004
5	Glucose (Dextrose)FDA LinkGeneric 02/2012 - 02/2003
5	Proteins (Proteins, Gene)FDA Link 06/2011 - 09/2007
5	landiololIBA 10/2010 - 11/2007
4	Antisense OligonucleotidesIBA 12/2016 - 05/2007
4	Thioctic Acid (Lipoic Acid)IBA 05/2012 - 03/2011
4	PlacebosIBA 04/2012 - 03/2009
4	sivelestatIBA 04/2010 - 01/2006
3	Peroxidase (Myeloperoxidase)IBA 06/2012 - 04/2003
3	Atrial Natriuretic Factor (ANF)IBA 04/2012 - 09/2008
3	SolutionsIBA 02/2012 - 09/2007
3	danaparoid (Orgaran)FDA Link 12/2011 - 01/2008
3	SodiumIBA 05/2011 - 01/2006
3	Anti-Bacterial Agents (Antibiotics)IBA 01/2011 - 09/2008
3	CreatinineIBA 01/2011 - 09/2005
3	Antithrombin IIIIBA 07/2010 - 02/2008
3	Anesthetics (Anesthetic Agents)IBA 01/2009 - 06/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2008 - 04/2003
3	CollagenIBA 07/2007 - 05/2007
2	HSP47 Heat-Shock Proteins (Heat Shock Protein 47)IBA 12/2016 - 06/2007
2	nafamostatIBA 06/2015 - 01/2007
2	Histones (Histone)IBA 01/2015 - 03/2013
2	Crystalloid SolutionsIBA 10/2012 - 01/2009
2	potassium ascorbyl tocopheryl phosphateIBA 07/2012 - 01/2011
2	Glutathione (Reduced Glutathione)IBA 06/2012 - 03/2012
2	cepharanthineIBA 11/2011 - 11/2011
2	Blood Glucose (Blood Sugar)IBA 10/2011 - 08/2008
2	Adrenergic Agents (Adrenergic Drugs)IBA 06/2011 - 03/2009
2	dihydrolipoylhistidineIBA 05/2011 - 03/2011
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2011 - 06/2002
2	Doripenem FDA Link 01/2011 - 01/2010
2	ThrombomodulinIBA 10/2010 - 03/2010
2	Protein CIBA 10/2010 - 03/2010
2	Free RadicalsIBA 07/2010 - 06/2002
2	Secretory Proteinase Inhibitory ProteinsIBA 04/2010 - 08/2008
2	AntithrombinsIBA 03/2010 - 04/2003
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 12/2009 - 05/2007
2	CeruletideIBA 10/2009 - 07/2009
2	Analgesics (Analgesic Drugs)IBA 03/2009 - 12/2007
2	Epoprostenol (Prostacyclin)FDA LinkGeneric 02/2009 - 04/2003
2	NF-kappa B (NF-kB)IBA 10/2008 - 08/2008

Therapy/Procedure

10	Therapeutics 07/2012 - 02/2004
5	Punctures 03/2014 - 10/2008
5	Ligation 03/2014 - 10/2008
5	Critical Care (Surgical Intensive Care) 01/2014 - 02/2009
3	Kidney Transplantation 07/2012 - 08/2010
3	Hemodiafiltration 12/2011 - 01/2010
3	Aftercare (After-Treatment) 12/2011 - 02/2009
3	Analgesia 12/2010 - 12/2007
2	Epidural Anesthesia 10/2012 - 12/2010
2	Hemofiltration 07/2012 - 12/2011
2	Subcutaneous Injections 06/2012 - 11/2011
2	Anesthesia 04/2012 - 12/2010
2	Radiotherapy 11/2011 - 02/2004
2	Conservative Treatment 11/2010 - 02/2004
2	Nephrectomy 08/2010 - 12/2004
2	Off-Pump Coronary Artery Bypass (Coronary Artery Bypass, Off Pump) 02/2010 - 11/2007
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 03/2009 - 10/2005
2	Parenteral Nutrition 09/2008 - 04/2008
2	Low-Level Light Therapy (LLLT) 09/2008 - 12/2007